Author(s): Miller OL Jr, Hamkalo BA, Thomas CA Jr
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Abstract The morphology of active structural and putative ribosomal RNA genes was observed by electron microscopy after lysis of fragile Escherichia coli cells. Conclusions drawn are: most of the chromosome is not genetically active at any one instant; translation is completely coupled with transcription; the 16S and 23S ribosomal RNA cistrons occur in tandem, in regions which are widely spaced on the chromosome.
This article was published in Science
and referenced in Biochemistry & Analytical Biochemistry