alexa Vitreous levels of proteins implicated in angiogenesis are modulated in patients with retinal or choroidal neovascularization.


Journal of Clinical & Cellular Immunology

Author(s): Huber M, Wachtlin J

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Abstract AIM: The aim of this study was to investigate the levels of pigment epithelium-derived factor (PEDF), angiopoietin 2, vascular endothelial growth factor (VEGF), and soluble VEGF receptor 1 (sVEGFR-1) in vitreous samples of patients suffering from age-related macular degeneration with choroidal neovascularization or from proliferative diabetic retinopathy (PDR). METHODS: Proteins in vitreous samples of 29 patients were quantified via enzyme-linked immunosorbent assays. RESULTS: Vitreous levels of sVEGFR-1 were significantly higher in age-related macular degeneration with choroidal neovascularization (p = 0.005) and in PDR (p = 0.003) versus controls. In analogue comparisons, PEDF was significantly decreased (p < 0.01). PDR was associated with significantly increased angiopoietin 2 and VEGF levels (p = 0.001 for both). CONCLUSION: The vitreous in retinal or choroidal neovascularization revealed a pro-angiogenic potential indicated by decreased PEDF or increased angiopoietin 2 levels compared to controls. However, higher amounts of sVEGFR-1 were concomitant, pointing to activation of an endogenous anti-angiogenic system in the protein network. Copyright © 2012 S. Karger AG, Basel. This article was published in Ophthalmologica and referenced in Journal of Clinical & Cellular Immunology

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