alexa Voltage-dependent P Q-type calcium channels at the frog neuromuscular junction


Chemotherapy: Open Access

Author(s): Nurullin LF, Mukhitov AR, Tsentsevytsky AN, Petrova NV, Samigullin DV

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It is well known that antagonists of N-type voltage-gated calcium channels inhibit the evoked quantal release of acetylcholine in amphibian neuromuscular synapses. This, however, does not exclude the functional expression of other types of voltage-gated calcium channels in these nerve terminals. Using immunocytochemistry, we detected the expression of the alpha1A subunit of P/Q-type calcium channels (that is otherwise typical of mammalian motor nerve endings) in the frog neuromuscular junction. In addition, we demonstrated that the P/Q-type channel blocker omega-agatoxin IVA (20 nM) reduced the action potential-induced calcium transient and significantly decreased both spontaneous and evoked mediator release. Our data indicates the functional expression of P/Q-type calcium channels in the frog motor nerve ending which participate in acetylcholine release.

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This article was published in Physiol Res and referenced in Chemotherapy: Open Access

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