Author(s): Magez S, Stijlemans B, Baral T, De Baetselier P
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Abstract African trypanosomes express a glycosylphosphatidyl inositol (GPI)-anchored variant-specific surface glycoprotein (VSG) as a protective coat. During infection, large amounts of VSG molecules are released into the circulation. Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology.
This article was published in Microbes Infect
and referenced in Journal of Tropical Diseases & Public Health