Author(s): Anderson JW, Grant L, Gotthelf L, Stifler LT
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Abstract OBJECTIVE: To review weight loss and maintenance for severely obese individuals enrolled in intensive behavioral weight loss program using very-low or low-energy diets. DESIGN: Chart review of consecutively treated patients between 1995 and 2002 seen at three weight loss centers. SUBJECTS: One thousand five hundred and thirty one patients with severe obesity (>or=40 kg/m(2)) treated in three cities ('Study Group'). Of these, 1100 completed the 12-week core curriculum ('Completer Group'). Weight loss >or=100 lbs (>45 kg) was seen in 268 patients ('100-Pound Group'). MEASUREMENTS: Charts were reviewed for baseline characteristics, weekly weights, follow-up weights and side effects. RESULTS: In the Study Group, average weight loss+/-s.e. for 998 women was 23.9+/-0.6 kg (18.5\% of initial body weight (IBW)) and for 533 men was 36.0+/-1.0 kg (22.5\%) over 30 weeks. For Completers, average weight loss for women was 30.8+/-0.6 kg (23.9\%) and for men was 42.6+/-1.1 kg (26.7\%) over 39 weeks. In the 100-Pound Group, average weight loss for women was 58.2+/-1.2 kg (41.5\%) in 65 weeks and for men was 65.7+/-1.5 kg (37.5\%) in 51 weeks. Side effects, assessed in 100 patients losing >45 kg, were mild to moderate in severity. Severe adverse events unrelated to the diet were noted in 5\% of patients and during weight loss 1\% had elective cholecystectomies. Follow-up weights were available for 86\% of Completers at an average of 72 weeks with average maintenance of 23 kg or 59\% of weight loss; follow-up weights were available for 94\% of the 100-Pound Group at an average of 95 weeks with average maintenance of 41 kg or 65\% of weight loss maintained. CONCLUSIONS: Intensive behavioral treatment with meal replacements is a safe and effective weight-loss strategy for selected severely obese individuals.
This article was published in Int J Obes (Lond)
and referenced in Journal of Obesity & Weight Loss Therapy