Author(s): Caporale C, Di Berardino I, Leonardi L, Bertini L, Cascone A,
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Abstract We have demonstrated that wheatwin1, a wheat pathogenesis-related protein of class 4 (PR4), has ribonuclease activity. Both native and recombinant proteins hydrolyse RNA from wheat coleoptils and have antifungal activity. Sepharose-bound wheatwin1 is able to interact with either wheat or Fusarium culmorum RNA. 3D modelling studies showed that, like ribonucleases A and T1, the action mechanism should involve two His residues, an Arg residue and an Asp residue.
This article was published in FEBS Lett
and referenced in Journal of Addiction Research & Therapy