alexa Whence directionality: guidance mechanisms in solitary and collective cell migration.
General Science

General Science

Journal of Biotechnology & Biomaterials

Author(s): Rrth P

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Abstract As individual cells or groups of cells move through the complex environment of the body, their migration is affected by multiple external cues. Some cues are diffusible signaling molecules, and some are solid biophysical features. How do cells respond appropriately? This perspective discusses the relationship between guidance input and the cellular output, considering effects from classical chemotaxis to contact-dependent guidance. The influences of membrane trafficking and of imposed constraints on directional movement are also considered. New insights regarding guidance and dynamic cell polarity have emerged from examining new cell migration models and from re-examining well known ones with new approaches and new tools. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in Dev Cell and referenced in Journal of Biotechnology & Biomaterials

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