alexa Whispering-gallery-mode biosensing: label-free detection down to single molecules.
Engineering

Engineering

Biosensors Journal

Author(s): Vollmer F, Arnold S, Vollmer F, Arnold S

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Abstract Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding. However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized. Here we describe the enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor, review its current implementations and applications, and discuss its future possibilities. This article was published in Nat Methods and referenced in Biosensors Journal

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