alexa Wing vein patterning in Drosophila and the analysis of intercellular signaling.
Genetics & Molecular Biology

Genetics & Molecular Biology

Gene Technology

Author(s): Blair SS

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Abstract The positioning and elaboration of ectodermal veins in the wing of Drosophila melanogaster rely on widely utilized developmental signals, including those mediated by EGF, BMP, Hedgehog, Notch, and Wnt. Analysis of vein patterning mutants, using the molecular and genetic mosaic techniques available in Drosophila, has provided important insights into how a combination of short-range and long-range signaling can pattern a simple epidermal tissue. Moreover, venation has become a powerful system for isolating and analyzing novel components in these signaling pathways. I here review the basic events of vein patterning and give examples of how changes in venation have been used to identify important features of cell signaling pathways. This article was published in Annu Rev Cell Dev Biol and referenced in Gene Technology

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