alexa Wnt β-catenin signaling and disease.
Oncology

Oncology

Journal of Cancer Science & Therapy

Author(s): Clevers H, Nusse R

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Abstract The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future. Copyright © 2012 Elsevier Inc. All rights reserved. This article was published in Cell and referenced in Journal of Cancer Science & Therapy

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