alexa World distribution of factor V Leiden.
Genetics

Genetics

Advancements in Genetic Engineering

Author(s): Rees DC, Cox M, Clegg JB

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Abstract We have analysed 3380 chromosomes (1690 unrelated individuals) from twenty-four populations for the presence of factor V Leiden, an important risk factor in venous thromboembolism. The allele frequency in 618 Europeans was 4.4\%, with the highest prevalence among Greeks (7\%). It was 0.6\% in Asia Minor. Factor V Leiden was not found in any of 1600 chromosomes from Africa, Southeast Asia, Australasia, and the Americas. This distribution may partly explain the rarity of thromboembolic disease in these populations. The high prevalence in Europeans suggests that screening for this mutation should be considered in some circumstances.
This article was published in Lancet and referenced in Advancements in Genetic Engineering

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