alexa Wound protectors reduce surgical site infection: a meta-analysis of randomized controlled trials.

Author(s): Edwards JP, Ho AL, Tee MC, Dixon E, Ball CG

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Abstract OBJECTIVE: A meta-analysis of randomized clinical trials (RCTs) was conducted to evaluate whether wound protectors reduce the risk of surgical site infection (SSI) after gastrointestinal and biliary tract surgery. BACKGROUND: The effectiveness of impervious wound edge protectors for reduction of SSI remains unclear. METHODS: A systematic review was conducted in Medline, EMBASE, and the Cochrane Library to identify RCTs that evaluate the risk of SSI after gastrointestinal and biliary surgeries with and without the use of an impervious wound protector. The pooled risk ratio was estimated with random-effect meta-analysis. Sensitivity analyses were performed to examine the impact of structural design of wound protector, publication year, study quality, inclusion of emergent surgeries, preoperative antibiotic administration, and bowel preparation on the pooled risk of SSI. RESULTS: Of the 347 studies identified, 6 RCTs representing 1008 patients were included. The use of a wound protector was associated with a significant decrease in SSI (RR = 0.55, 95\% CI 0.31-0.98, P = 0.04). There was a nonsignificant trend toward greater protective effect in studies using a dual ring protector (RR = 0.31, 95\% CI 0.14-0.67, P = 0.003), rather than a single ring protector (RR = 0.83, 95\% CI 0.38-1.83, P = 0.64). Publication year (P = 0.03) and blinding of outcome assessors (P = 0.04) significantly modified the effect of wound protectors on SSI. CONCLUSIONS: Our results suggest that wound protectors reduce rates of SSI after gastrointestinal and biliary surgery. This article was published in Ann Surg and referenced in

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