alexa X chromosome-linked muscular dystrophy (mdx) in the mouse.
Immunology

Immunology

International Journal of Inflammation, Cancer and Integrative Therapy

Author(s): Bulfield G, Siller WG, Wight PA, Moore KJ, Bulfield G, Siller WG, Wight PA, Moore KJ

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Abstract An X chromosome-linked mouse mutant (gene symbol, mdx) has been found that has elevated plasma levels of muscle creatine kinase and pyruvate kinase and exhibits histological lesions characteristic of muscular dystrophy. The mutants show mild clinical symptoms and are viable and fertile. Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome.
This article was published in Proc Natl Acad Sci U S A and referenced in International Journal of Inflammation, Cancer and Integrative Therapy

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