alexa Zika virus impairs growth in human neurospheres and brain organoids
Microbiology

Microbiology

Journal of Chemical Biology & Therapeutics

Author(s): Garcez PP, Loiola EC, da Costa RM, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK

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Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased significantly in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. Here, we examine the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we show that ZIKV targets human brain cells, reducing their viability and growth as neurospheres and brain organoids. These results suggest that ZIKV abrogates neurogenesis during human brain development.

This article was published in Science and referenced in Journal of Chemical Biology & Therapeutics

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