alexa Zika virus impairs growth in human neurospheres and brain organoids.
Neurology

Neurology

Journal of Neuroinfectious Diseases

Author(s): Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, , Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P,

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Abstract Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. We examined the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we showed that ZIKV targets human brain cells, reducing their viability and growth as neurospheres and brain organoids. These results suggest that ZIKV abrogates neurogenesis during human brain development. Copyright © 2016, American Association for the Advancement of Science. This article was published in Science and referenced in Journal of Neuroinfectious Diseases

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