alexa Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses
Microbiology

Microbiology

Journal of Chemical Biology & Therapeutics

Author(s): Song H, Qi J, Haywood J, Shi Y, Gao GF

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The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis.

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This article was published in Nat Struct Mol Biol and referenced in Journal of Chemical Biology & Therapeutics

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