alexa Zinc deficiency and corticosteroids in the pathogenesis of alcoholic brain dysfunction--a review.
Toxicology

Toxicology

Journal of Clinical Toxicology

Author(s): Menzano E, Carlen PL

Abstract Share this page

Abstract Chronic alcoholism is associated with hypercortisolemia and low serum zinc (Zn). Hypercortisolemia could be responsible for alcoholic cerebral atrophy and is also associated with enhanced NMDA neurotoxicity. It is hypothesized that low brain Zn, noted in chronic alcoholics, enhances NMDA excitotoxicity and ethanol withdrawal seizure susceptibility. Also, Zn deficiency can produce neuronal damage through increased free radical formation. Clinically, Zn replacement therapy may be a rational approach to the treatment of alcohol withdrawal seizures and alcohol-related brain dysfunction.
This article was published in Alcohol Clin Exp Res and referenced in Journal of Clinical Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

  • Uri Galili
    A novel approach for inhibiting progression of flu virus infection at early stages of the disease by inhalation of -gal/sa liposomes
    PPT Version | PDF Version

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords