alexa Zinc deficiency and corticosteroids in the pathogenesis of alcoholic brain dysfunction--a review.


Journal of Clinical Toxicology

Author(s): Menzano E, Carlen PL

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Abstract Chronic alcoholism is associated with hypercortisolemia and low serum zinc (Zn). Hypercortisolemia could be responsible for alcoholic cerebral atrophy and is also associated with enhanced NMDA neurotoxicity. It is hypothesized that low brain Zn, noted in chronic alcoholics, enhances NMDA excitotoxicity and ethanol withdrawal seizure susceptibility. Also, Zn deficiency can produce neuronal damage through increased free radical formation. Clinically, Zn replacement therapy may be a rational approach to the treatment of alcohol withdrawal seizures and alcohol-related brain dysfunction.
This article was published in Alcohol Clin Exp Res and referenced in Journal of Clinical Toxicology

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