OMICS International OMICS International is a scientific organization that drives the progress of research through open access journals and organizes international conferences, The best in science news, commentary, and research. Journal of Clinical Trials Volume 8, Issue 3 First Clinical Application of New Bone Substitute Material to the Alveolar Cleft Keiko Matsui , Tetsu Takahashi , Tadashi Kawai and Shinji Kamakura Changes in Numbers of Randomized vs NonRandomized Clinical Trials Recent Evidence of Shifting Cancer Drug Development Pathways Laura Vidal Boixader , Kelly Kevelin Cartis , Liat Vidal , Jozsef Palatka , Jim Wahl , Nicholas Kenny and Keren Rachel Moss Personalized Chimeric Antigen Receptor T Cell Immunotherapy for Patients with Recurrent Malignant Gliomas Ye Cheng , Teer Ba , Jianqiang Li , Feng Ling and Qingtang Lin Success Rate and Possible Causes of Failures of Phase 3 Clinical Trials in Patients with Breast Cancer A Systematic Review Mitsugu Ikeda , Tatsuya Ochibe and Masahiro Tohkin The Effect of Avastin on Posterior Capsular Opacification after Phacoemulsification A Randomized Controlled Trial Mitsugu Ali Mostafaei , Mohammad Mirzaei , Nazli Taheri , Sabouheh Ghorbani and Neda Parnianfard