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Acute Liver Failure

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  • Acute liver failure

     Acute liver failure (ALF) is a rare syndrome defined by a rapid decline in hepatic function characterised by jaundice, coagulopathy (INR >1.5), and hepatic encephalopathy in patients with no evidence of prior liver disease.The interval from the onset of jaundice to the development of encephalopathy occurs within 24 to 26 weeks and may further classify ALF into categories based on hyperacute, acute, or subacute presentations.Although clinical jaundice is considered a defining feature of ALF, it may not always be present, particularly in hyperacute presentations.

    Typical symptoms

    Yellowing of your skin and eyeballs (jaundice), Pain in your upper right abdomen, Abdominal swelling, Nausea, Vomiting, A general sense of feeling unwell (malaise), Disorientation or confusion, Sleepiness

  • Acute liver failure

     Therapeutic aspects

    Treatments for acute liver failure Acute liver failure treatments may include: Medications to reverse poisoning. Acute liver failure caused by acetaminophen overdose or mushroom poisoning is treated with drugs that can reverse the effects of the toxin and may reduce liver damage. Liver transplant. When acute liver failure can't be reversed, the only treatment may be a liver transplant. During a liver transplant, a surgeon removes your damaged liver and replaces it with a healthy liver from a donor. Treatments for complications Control signs and symptoms you're experiencing and try to prevent complications caused by acute liver failure.

  • Acute liver failure

     Statistics

    Alcohol screening was done using CAGE and AUDIT tools; BMI was measured by physical exam; liver tests (ALT, AST, GGTP, bilirubin, ALP, ALT/AST), anti-HCV, HBsAg, and γ-globulins were checked by laboratory analysis; an abdominal ultrasound was performed for all patients. Provisional diagnoses were formed for all participants according to our established algorithm. In total, 4,768 participants completed screening. Socio-demographic data: male 1,671 (33.42%), female 3,329 (66.58%), average age 45 years, average BMI 26.2 kg/m2. Average BMI >25 kg/m2 was observed among the following occupational groups: retired, disabled, military and businessmen. Health care workers and students were the “slimmest” occupational groups, with only 24.7% and 21.8% having BMI >25 kg/m2 respectively.

     

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