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Ampullary Cancer

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  • Ampullary Cancer

    Ampullary cancer is a malignant tumor that arises from the Ampulla of Vater, the last centimeter of the common bile duct as it passes through the duodenum, the first section of the intestine. All pancreatic and biliary secretions enter the duodenum through the Ampulla of Vater. A tumor blocking  the Ampulla of Vater will interfere with drainage of the pancreatic and biliary secretions into the intestine. Jaundice results when the drainage of bile into the duodenum is blocked causing it to accumulate in in the bloodstream. Jaundice, the yellowing of the skin, is typically one of the first symptoms present with Ampullary cancer.

  • Ampullary Cancer

    The standard treatment for ampullary cancer is a pylorus preserving Whipple operation.Five year survival for ampullary tumors is excellent if the tumor does not invade the adjacent pancreas. If your doctors determine that you have ampullary cancer, the standard approach is to remove the tumor from the ampulla of Vater with a procedure called pancreaticoduodenal resection, or Whipple procedure. This procedure involves the resection, or removal, of the tumor in the affected portion of the ampulla of Vater and the surrounding areas. The procedure is performed using endoscopic instruments. In some centers, the long, narrow cameras and tools used to perform the procedure are inserted through small incisions (cuts) in the abdomen. 

  • Ampullary Cancer

    In the Far East, Korea demonstrated highly significant increasing mortality trends for both sexes [men (4.8–7.8), p<0.001; women (2.5–4), p<0.01), while women in Japan showed an increasing trend that was significant (p<0.05). In France, a trend towards increasing mortality was observed among women (p<0.001). An upward mortality trend in women achieving significance was also seen in Malta, Bulgaria, Greece, and Germany (p<0.05). A decline in mortality was seen in both sexes only in Canada [men (7.5–6.4), women (5.9–5); p<0.01], while for men there was a downward trend noticeable in Ireland, Switzerland, Austria, the UK, and Poland [p<0.05].

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