Ataxia is typically defined as the presence of abnormal, uncoordinated movements. An unsteady, staggering gait is described as an ataxic gait because walking is uncoordinated and appears to be ‘not ordered’. Ataxia can also refer to a group of neurological disorders in which motor behavior appears uncoordinated.
Causes: Inherited/Genetic: Autosomal Dominant; Autosomal Recessive; X-Linked; Associated with a Mitochondrial Disorder. Acquired: Structural/Demyelinating; Toxic/Metabolic; Paraneoplastic; Infectious/Postinfectious; Autoimmune. Idiopathic: Cerebellar form of multiple system atrophy (known as MSA); Idiopathic cerebellar degeneration.
Therapy for ataxic patients is multi-modal. Pharmacological treatment has been beneficial in a small number of patients with specific ataxias and further research is ongoing worldwide. GABAergic agents such as clonazepam, beta-blockers such as propranolol, or Primidone may reduce the prominence of some cerebellar tremors. The Prevalence of Ataxia is 0.3 per 100 000 (or 1 in 330 000).The region east of Moscow with a prevalence of 1 in 270 000 and in central Asia with an overall prevalence of 1 in 200 000.