It is a condition, which is characterized by delays the social function, speech as well as motor skills. The cause of childhood disintegrative disorder is unknown. Childhood disintegrative disorder is also known as Heller's syndrome and disintegrative psychosis. Delay or lack of spoken language, Impairment in nonverbal behaviours, Inability to start or maintain a conversation, Lack of play, Loss of bowel and bladder control, Loss of language or communication skills, Loss of motor skills, Loss of social skills, Problems forming relationships with other children and family members. About half the children diagnosed with Childhood disintegrative disorder have an abnormal electroencephalogram (EEG). EEGs measure the electrical activity in the brain generated by nerve transmission (brain waves). Children with Childhood disintegrative disorder have at least 2 years of normal development in all areas—language understanding, speech, skill in the use of large and small muscles, and social development. The prevalence of Childhood disintegrative disorder is 1 in 100,000 boys and ratio of boys to girls is estimated to be 8 boys to 1 girl. There is no treatment for CDD. As neurological complications especially epilepsy are common and these children function at the level of severe to profound mental retardation a multidisciplinary approach is necessary.
Translational toolsas applicable to autoimmune disorders: antibody-proteases as a generation of highly informative and unique biomarkersto monitor subclinical and clinical stages of demyelination in multiple sclerosis (MS) PPT Version |