Deep vein thrombosis, or deep venous thrombosis, (DVT) is the formation of a blood clot (thrombus) within a deep vein, predominantly in the legs. Non-specific signs may include pain, swelling, redness, warmness, and engorged superficial veins. DVT often develops in the calf veins and "grows" in the direction of venous flow, towards the heart. When DVT does not grow; it can be cleared naturally and dissolved into the blood (fibrinolysis).
Study of 2516 ICU patients received prophylaxis of a deep vein thrombosis (DVT) and venous thromboembolic complications (VTEC). The frequency of renal failure was 19.8%. Mortality rate in patients with acute renal failure (ARF) was 34% and in patients without ARF 17%. An analysis of drugs for prophylaxis of DVT and VTEC which were used in patients with ARF showed that the prophylaxis was performed without a taking in account a significance of such complication.
The basic treatments for the disease are Anticoagulation, which prevents further coagulation, home treatment, stockings, walking, and repeat imaging and IVC filters, thrombolysis, and thrombectomy. The aims of the physicians are to prevent clot becoming larger, clot becoming lose and traveling to lungs, new clot formation and Post thrombotic syndrome.
On Disease The current major research on the diseases are efficacy of low doses of heparin for the prevention of the DVT after a major surgery, accuracy of the clinical assessment for DVT, Decreased plasma levels of activated factor VII in patients with deep vein thrombosis etc.