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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephropathy
     (IMN) is a disease in which glomerular basement membrane becomes thickening by light microscopy on renal biopsy and it represents a major cause of primary nephrotic syndrome in adults. The main sign of Membranous Nephropathy is the loss of proteins, primarily albumin, from the blood into the urine(proteinuria).

  • Membranous nephropathy

    Disease pathophysiology:

    Someone with membranous nephropathy may discharge several hundreds of milligram of proteins each day, up to more than 10g/24h with advanced kidney disease. Glomerular filtration rate (GFR) is performed to determine residual . other tests may be done to see how well the kidneys are working, which include blood urea nitrogen, blood creatinine, creatinine clearance test, etc.

     

  • Membranous nephropathy

    Disease statistics:

    In adults the most common disease is mesangiocapillary glomerulonephritis (30-40%), followed by focal and segmental glomeruloesclerosis (15-25%) and minimal change disease (20%). Its main cause is diabetic nephropathy. It usually presents in a patient’s 40s or 50s. Of the glomerulonephritis cases approximately 60% to 80% are primary, while the remainder are secondary .

     

  • Membranous nephropathy

    Disease treatment:

    The treatment of the patients is generally based on correction of proteinuria and of hypertension or hyperlipidademia, when present. Angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin receptor blockers (ARB) are usually given both for treating hypertension and for reducing proteinuria".

     

  • Membranous nephropathy

    Major research on disease: 

    Tacrolimus Treatment of Patients With Idiopathic Membranous NephropathyPLA2R is a protein found in cells in the kidney, and is involved in the development of MN. 

     

Expert PPTs

Speaker PPTs

  • Hayam I Gad
    Effects of Pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of Diabetic nephropathy in an experimental model of diabetic renal disease
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