Meniere's (say: "men-ears") disease is a problem with your inner ear. No one knows exactly what causes it, but it may be related to a build up of fluid in the inner ear. Although it can be troublesome, Meniere's disease is not contagious, and it isn't fatal.Between attacks, Reissner's membrane may reattach itself, the chemical balance is restored, and symptoms remit.
During the acute attack the excessive endolymphatic fluid pressure causes distension and rupture of Reissner's membrane. This results in the release of potassium-rich endolymph into the perilymphatic space and causes injury to the sensory and neural elements of the inner ear, which manifests clinically as sudden hearing loss, tinnitus, and vertigo.
Surgical therapy of MD is indicated for those patients who fail medical treatment. Surgical treatments are directed at relief of the putative cause (endolymphatic sac) or at deafferentation of the affected ear (vestibular nerve section, labyrinthectomy [surgical or chemical]). The procedures are discussed in order of increasing invasiveness and complexity.
Diuretics and dehydrating agents. Diuretics have been used since the 1930’s, when Furstenberg et al. (1934) published their findings concerning the use of diuretics and dietary salt restriction. Diuretics (hydrochlorothiazide, acetazolamide or a combination of hydrochlorothiazide and triamterene) are still the first choice in the medical therapy of Meniere’s disease (Claes & Van De Heyning 2000).
Major research on disease:
Medications for an acute attack of Meniere's.Only one double-blinded, cross-over, placebo-controlled study has been published (Van Deelen & Huizing 1986), where the effects of using diuretics were shown to control vertigo, but no long-term effect on hearing levels was found."