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Disease pathophysiology:
Primary immunodeficiency refers to an immune system which from birth is either broken or completely missing. It is not a condition acquired after birth from infection or accident. It is a genetic malfunction, unique to an individual, and can affect just one cell or many parts of the immune system. Approximately 29,000 Canadians suffer from Primary Immunodeficiency. Over 70% are undiagnosed.
Disease statistics:
Primary immunodeficiency disorders (PIDs) are a heterogeneous group of inherited disorders that affect different components of the immune system. There are more than 150 different disorders which have been described till date. Despite major advances in the molecular characterization of PIDs over the last 20 years, many patients remain undiagnosed or are diagnosed too late with severe consequences.
Disease treatment:
Antibiotics are given as soon as a fever or another sign of an infection develops and before surgical and dental procedures, which may introduce bacteria into the bloodstream. If a disorder (such as severe combined immunodeficiency) increases the risk of developing serious infections or particular infections, people may be given antibiotics to prevent these infections.