Pulmonary embolism is a sudden blockage in a lung artery. Blockage usually is caused by a blood clot that travels to the lung from a vein in the leg. Because pulmonary embolism almost always occurs in conjunction with deep vein thrombosis, most doctors refer to the two conditions together as venous thromboembolism. Pulmonary embolism can be life-threatening, but prompt treatment can greatly reduce the risk of death. However, it was discovered that the TT genotype of MTHFR: 677 C>T polymorphism in men increases the risk of PE in comparison to controls.
Disease statistical analysis in Russia on pulmonary embolism gave the result as the age distributions of our male and female patients were found to be significantly different. For men, the distribution has two maxima, whereas for women it has only one maximum, which is between the two. This fact stimulated us to perform a sex-specific analysis. No statistically significant difference has been found between distributions of the three genes in our PE patients and healthy controls.