alexa Abstract | A Comparative Study of the Effect of Gabapentin, Topiramate, Levetiracetam and Zonisamide for Neuropathic Pain Induced by Anticancer Drug (Vincristine) in Rats

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Background: Neuropathic pain syndrome is a frequently occurring, disabling disease. Many anticancer drugs which are used to treat solid tumors cause neuropathic pain as their dose limiting side effect. Current treatment options are still relatively poor. Objective: The present study was designed to compare the effect of gabapentin, topiramate, levetiracetam and zonisamidefor treatment of neuropathic pain induced by anticancer drug(vincristine) in albinorats using thermal method. Materials and Methods: Neuropathic pain was induced by injecting vincristine (100μg/kg) intraperitoneally daily for 14 days in rats. Behavioural testing for thermal hyperalgesia was assessed 24 hours after each injection by the hot-plat method. After 14 days rats were divided into five groups of six animals each. Group I was treated with distilled water as control group, group II was treated with oral gabapentin (60 mg/kg), group III received oral topiramate (40 mg/kg), group IV was treated with oral levetiracetam (120 mg/kg) and group V received zonisamide (50 mg/kg).The antihyperalgesic effect of drugs was assessed by the hot-plate method 24 hours after each administration. Statistical analysis was done by two way analysis of variance (ANOVA) followed by post hoc test. Results: Gabapentin, topiramate and zonisamide treated groups showed asignificant(P < 0.0001) increase hot-plate latency as compared to control group. Levetiracetam treated group however, did not show a significant increase in hot-plate latency. Conclusion: In vincristine induced neuropathic pain gabapentin, topiramate and zonisamide appearto be promising drugs although they act by different mechanisms

To read the full article Peer-reviewed Article PDF image

Author(s): Punam Jakhar, Omi Chouhan, Anusuya Gehlot, R. K. Rathore, Raghuveer Choudhary, Rajesh Chaudhary


Gabapentin, levetiracetam, topiramate, vincristine induced neuropathic pain, zonisamide, Cancer Screening,Exercise and Cancer,Alternative Cancer Medicines,Cancer Prevention from Nuts,Cancer Pathology

Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version