alexa A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab | Abstract
ISSN: 2167-7921

Journal of Arthritis
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Rheumatoid (RA) and Psoriatic arthritis (PsA) are characterized by extensive synovitis resulting in bone destruction in both diseases and new bone formation in PsA. Objective: This prospective study analyzed interleukin (IL)-6, IL-17, IL-23, tumor necrosis factor (TNF)-α serum and synovial fluid (SF) levels and osteoprotegerin (OPG), bone-specific alkaline phosphatase (BAP) and D-vitamin (D-Vit) serum levels in RA and PsA patients before and after anti-TNF-α. Methods: 15 RA and 15 PsA patients with knee effusion and starting adalimumab (ADA) treatment were enrolled. Serum and SF from inflamed knee joint samples were obtained at baseline and after 24 weeks of treatment. Statistical analysis was performed using Graph Pad 5.0 statistical software. Results: In RA and PsA, SF IL-6, IL-17, and TNF-α were higher than serum levels while higher serum IL-23 was detected than in SF. Higher serum/SF IL-6, IL-23 and SF TNF-α were observed in RA than PsA, while serum IL-17 was higher in PsA than RA. Positive feedback among IL-6, IL-23, IL-17 and CRP and negative correlation between IL-17 and TNF-α in RA were found. In PsA, IL-23 correlated positively with IL-6. OPG correlated positively with ESR/CRP in RA and PsA. D-Vit correlated negatively with OPG and ESR in PsA. Higher BAP in RA than PsA and positive correlation with IL-6 in RA and with OPG in PsA were noticed. In PsA, IL-6 and OPG serum levels decreased significantly after 24 weeks ADA treatment. Conclusions: Distinct distribution of inflammatory cytokines and correlations with bone mediators were detected in RA and PsA. ADA affected inflammatory cytokines and bone mediators in PsA patients.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Maria Sole Chimenti, Paola Conigliaro, Maria Morello, Rossella Zenobi, Paola Triggianese, Carlo Perricone, Lucia Novelli, Sergio Bernardini and Roberto Perricone

Keywords

Synovial fluid, Inflammatory arthritis, Anti-TNF-α, Inflammatory cytokines, Bone mediators, D-vitamin, Joint Replacement, Rheumatoid Arthritis, Bone cancer, Bone metastasis, Bone spurs,Metabolism,Otitis Media,Inflammatory vasculitis,Rheumatoid vasculitis,Advances in Fibromyalgia Medication,Cytokine Immunobiology,Anti-inflammatory cytokines,Anti-inflammatory cytokines,Cytokines function,Cytokine therapy,Cytokine array,Cytokine production,Intracellular cytokine staining,Cytokine inhibitors,Cytokine signaling,Macrophage cytokines,Pro-inflammatory cytokine,Pro-inflammatory cytokine,Cytokine inflammation,Role of cytokines,Role of cytokines,Role of cytokines,Cytokine,Cytokine storm,Cytokine release syndrome,Rheumatoid Arthritis Diagnosis

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords