alexa Abstract | 1,3,4-oxidiazole thiones as inflammation inhibitors.

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access


5-[2-Hydroxy phenyl]-1,3,4-oxadiazole-2 (3H) thione (II) was synthesized by cyclization of salicylic acid hydrazide (I). II was further converted to 5-[2-hydroxy phenyl ]-3-[arylaminomethyl)-1,3,4-oxadiazole 2(3H) thiones (III) and their hydrochlorides (IV). All the compounds were evaluated for their ability to inhibit carrageenin induced rat's paw oedema. IIIc and IIIe were found to have better activity than phenylbutazone with higher ALD 50 values.

Author(s): S Saxena M Verma AK Saxena K Shanker

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