alexa Abstract | (1-(4-Methoxybenzyl)-1-H-1,2,3-triazol-4-yl)methanol (MBHTM) accelerated copper-catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) at low catalyst loading in PEG-H2O as green reaction media

Journal of Chemical and Pharmaceutical Research
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Abstract

Facile synthesis of diverse 1,4-disustituted 1,2,3-triazoles derivatives using readily accessible, cost effective, remarkably stable and easily tunable 1,2,3 triazole based ligand, (1-(4-Methoxybenzyl)-1-H-1,2,3-Triazol-4- yl)Methanol (MBHTM) in PEG-H2O as green reaction media has been developed . As compared to ligand free reaction, the dramatic rate enhancement of copper catalyze azide–alkyne cycloaddition (CuAAC) at low catalyst loading in PEG-H2O media has been observed. The present method provides high to excellent yields and thus considered to be the green “click chemistry” tool for synthetic applicationsc

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Author(s): Rajesh H Tale Venkatesh B Gopula Gopal K Toradmal Ashish D Raote Kalpana M Patil and R P Pawar

Keywords

Click Chemistry, Ligand, 1,2,3-triazoles, Polyethylene glycol, Cycloaddition, catalyst

 
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