alexa Abstract | (4+3) cycloaddition reactions in organic synthesis: Synthesis of Bishomomaprotiline [9,10-dihydro-9-(4-methylaminobutyl)-9,10- propanoanthracene]

Journal of Chemical and Pharmaceutical Research
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Abstract

The reactions between oxyallyl cations and 9-substituted anthracene to obtain 9,10-dihydro-9,10- propanoanthracene substituted have not yet been studied extensively. For this reason, we used (4+3) cycloaddition reactions of 9-(4-pentenyl)-anthracene with 1,1,3,3-tetrabromoacetone as key step for preparation of a homologue of maprotiline which has been synthesized and developed into a clinically useful drug for the treatment of depressant by Ciba-Geigy research group in Switzerland.

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Author(s): Adel AlSaeedi Usama Karama Mujeeb A Sultan and Mazahar Farooquia

Keywords

Oxyallyl Cations, (4+3) Cycloaddition Reactions, Homologue, Ludiomil, 1,1,3,3-Tetrabromoacetone, Bishomomaprotiline

 
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