alexa Abstract | 46. Antidiabetic & Hypolipidemic Potential of Alocasia indica Schott. Leaves in Streptozotocin Induced Diabetic Rats

International Journal of Drug Development and Research
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Abstract

The present study was designed to investigate antidiabetic & hypolipidemic potential of alcoholic extract of Alocasia indica Schott. leaves (Araceae) in streptozotocin induced diabetic rats. Diabetes was induced by single intraperitoneal injection of streptozotocin (60 mg kg-1). Graded doses (200 & 400 mg kg-1) of test extracts were studied in both normal & streptozotocin induced diabetic rats for the period of 21 days. Glibenclamide (10 mg kg-1) was used as standard drug. Blood glucose levels & body weight was monitored at specific intervals and lipid profile parameters such as serum cholesterol, serum triglyceride & high density lipoprotein (HDL) were also assessed in experimental animals. The statistical data indicated significant increase in body weight & decrease in blood glucose level & serum lipid profiles (cholesterol & triglyceride) in test extract treated animals. These results could explain the basis for the use of this plant extract to manage serum glucose level and lipidemia associated with diabetes mellitus.

| Peer-reviewed Full Article image

Author(s): S H Patil S A Sreenivas P V Deshmukh M Srikanth Avijit Choudhury A E Wagh

Keywords

Alocasia indica, diabetes mellitus, hyperlipidemia Streptozotocin, Glibenclamide

 
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