alexa Abstract | 50. Development of Solid Self Micro Emulsifying Drug Delivery System with Neusilin US2 for Enhanced Dissolution Rate of Telmisartan

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Aim of present study was to develop solid self micro emulsifying drug delivery system (S-SMEDDS) with Neusilin US2 for enhancement of dissolution rate of Telmisartan (TEL). SMEDDS was prepared using Oleic acid, Tween 80 and PEG 400 as oil, surfactant and cosurfactant respectively. For formulation of stable SMEDDS, micro emulsion region was identified by constructing pseudo ternary phase diagram containing different proportion of surfactant: co-surfactant (Km value 1:1, 2:1 and 3:1), oil and water. Prepared SMEDDS was evaluated for thermodynamic stability study, dispersibility tests, globule size and zeta potential. S-SMEDDS was prepared by adsorption technique using Neusilin US2 as solid carrier. Prepared S-SMEDDS was evaluated for flow properties, drug content, reconstitution properties, FTIR, SEM, DSC and in-vitro dissolution study. Results showed that prepared liquid SMEDDS passed dispersibility test with good thermodynamic stability. Globule size was found to be 30.2 nm with polydispersity index 0.116 and -5.80 mV zeta potential. S-SMEDDS showed good flow property and drug content. Reconstitution properties of S-SMEDDS showed spontaneous micro emulsification with globule size 32.4 nm and polydispersity index 0.219 and -6.32 mV zeta potential. Results of in-vitro dissolution showed that there was enhancement of dissolution rate of TEL as compared with that of plain TEL. From the results study concluded that, Neusilin US2 can be used to develop S-SMEDDS by adsorption technique to enhance dissolution rate of poorly water soluble drug such as TEL.

| Peer-reviewed Full Article image

Author(s): Bhagwat Durgacharan A DSouza John I

Keywords

Telmisartan, S-SMEDDS, Neusilin US2, Pseudo ternary phase diagram

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords