alexa Abstract | A comparative study of excretion of the components after oral administration of pure baicalin radix scutellariae and scutellariae-paeoniae couple extracts to normal and ulcerative colitis rats.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Radix scutellariae and Scutellariae-Paeoniae couple extracts are the well-known Traditional Chinese Medicine (TCM) to treat ulcerative colitis. Baicalin, wogonoside, baicalein and wogonin are the main effective ingredients in Radix scutellariae. This study was carried out to investigate the excretion profiles of baicalin, wogonoside, baicalein and wogonin in urine and feces after oral administration of pure baicalin, Radix scutellariae and Scutellariae- Paeoniae couple extracts to rats with ulcerative colitis (UC) and to compare the different profiles of urine with normal rats. The levels of the four flavones in urine and feces were measured by a rapid and sensitive high-performance liquid chromatography (HPLC) method. All the rats were divided randomly into two groups (ulcerative colitis and normal groups). Each group contained three subgroups: pure baicalin, Radix scutellariae and Scutellariae- Paeoniae couple subgroup. Each group received oral administration of pure baicalin, Radix Scutellariae and Scutellariae-Paeoniae couple extracts; which contained nearly the same amounts of baicalin at a dosage of 200 mg/kg. All the four flavones occurred in the rat urine and feces, but the general levels of baicalin and wogonoside were predominant in urine and baicalein and wogonin were predominant in feces. The cumulative excretion quantities of these flavones in rat urine or feces were significantly different among these groups (P < 0.05). Meanwhile, the cumulative excretion quantities of these flavones in UC rat urine were less than that in normal rat. Conclusion: Our results suggest that the combination of Radix Scutellariae and Radix Paeoniae Alba might afford higher absorption and excretion, and that the rate of utilization of pure baicalin, Radix scutellariae or Scutellariae- Paeoniae couple is increased in UC.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Wei Liu Shuai Zhang Xiaohuan Fu Hongjuan Li Wei Xiao ZhenQiu Zhang


Flavones, Excretion, Urine, Feces

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us