alexa Abstract | A Convenient one pot synthesis and antimicrobial activity of 10- methyl 14,15-diimino benzothiazolo[2,3-b] pyrimido [5,6-e] pyrimido [2,3-b] benzothiazole and their substituted derivatives

Der Pharmacia Sinica
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Research Article Open Access


2-amino-6-methyl benzothiazole (1) and bis (methylthio) methylene malanonitrile (2) were refluxed in N,N-dimethyl formamide (DMF) in presence of catalytic amount of anhydrous potassium carbonate to afforded 3-cyano-4-imino-2-methylthio-8-methyl-4H-pyrimido[2,1-b] benzothiazole (3). The latter were further reacted with different substituted 2-amino benzothiazole (4). Afforded to form10-methyl-14, 15-diimino benzothiazolo[2, 3-b] pyrimido [5,6-e] pyrimido [2, 3-b] benzothiazole (5) and its substituted derivatives. All these synthesized compounds were characterized by elemental analysis and spectral data.

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Author(s): Sambhaji P Vartale Nilesh K Halikar and Sharad V Kuberkar

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