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Research Paper Open Access
The synthesis benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles (5a-j) were achieved by cyclocondensation of arylidene amino-benzo[d]imidazole-2-thiols (3a-j) with mercaptoacetic acid followed by cyclization with 2-(phenylmethylene)malononitrile. Further more, the present study aimed at the evaluation of in vitro antiinflammatory activity and antioxidant activity of synthetic compounds. All tested compounds showed appreciable activity against the standard drugs.
Benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitrile, mercaptoacetic acid, Michael addition, cyclo condensation, antiinflammatory activity, antioxidant activity