alexa Abstract | A facile synthesis, <i>in vitro</i> antiinflammatory and antioxidant activity of novel benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

The synthesis benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles (5a-j) were achieved by cyclocondensation of arylidene amino-benzo[d]imidazole-2-thiols (3a-j) with mercaptoacetic acid followed by cyclization with 2-(phenylmethylene)malononitrile. Further more, the present study aimed at the evaluation of in vitro antiinflammatory activity and antioxidant activity of synthetic compounds. All tested compounds showed appreciable activity against the standard drugs.

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Author(s): SR Malladi R Anisetti PR Rao

Keywords

Benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitrile, mercaptoacetic acid, Michael addition, cyclo condensation, antiinflammatory activity, antioxidant activity

 
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