alexa Abstract | A facile synthesis of (±)-Baclofean via Fe(acac)3 catalyzed Michael addition and Pinner reaction

Journal of Chemical and Pharmaceutical Research
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An effective and convenient procedure for the Micha el addition using Fe (acac) 3 (1 mol %) as an effective catalyst, catalyses the Michael addition reaction of nitro me thane to α -cyano cinnamate ester followed by Pinner reaction to produce corresponding diethyl 2-(1-(4-chlorophenyl) -2-nitroethyl)malonate with good yields under mild condition with high yield. Accordingly, we applied this synt hetic strategy for synthesis of (±)- Baclofean

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Author(s): Manojkumar U Chopadea and Anil U Chopade


Michael addition, Fe(acac)3, Nitro methane, α-Cyano cinnamic ester, Amino acids., facile synthesis, Baclofean , Michael addition

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