alexa Abstract | A Factorial study on the formulation and evaluation of Pioglitazone controlled release Matrix Tablets

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The objective of the present study was to formulate pioglitazone matrix tablets for controlled release. Controlled release matrix tablets of pioglitazone were developed for better control of blood glucose levels by prolonging its duration of action and to reduce GI disturbances with improved patient compliance. The tablets were prepared by wet granulation technique employing 50% w/w Hydroxypropyl methylcellulose K 15M as release controlling agent. Lactose and dicalcium phosphate were used as diluents. Polyvinyl pyrrolidone and polyethylene glycol 6000 were used as solubilizers. A 23 factorial design was applied for study and evaluation of the individual and combined effects of type of diluent (Factor A), polyvinyl pyrrolidone (Factor B) and polyethylene glycol 6000 (Factor C) on drug release from pioglitazone matrix tablets. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. All Pioglitazone matrix tablets followed first order kinetics, Higuchi drug release kinetics with diffusion as the dominant mechanism of drug release. As per Korsmeyer-Peppas equation, the release exponent 'n' ranged 0.663-0.892 indicating that drug release from all the batches was by non-Fickian diffusion mechanism. The type of diluent and solubilizers had highly significant effect on the drug release from the tablets (P < 0.01). The results of drug release study indicated that lactose as diluent gave relatively higher release rate than dicalcium phosphate. Polyethylene glycol 6000 gave relatively higher release than polyvinyl pyrrolidone. A combination of factors A, B and C gave slow, controlled and complete release of pioglitazone over a period of 24 hours.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): K R Koteswara Rao A Siva Rama Prasad

Keywords

Piogliatzone matrix tablets, solubilizers, polyvinyl pyrrolidone, polyethylene glycol 6000, kinetic parameters

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords