alexa Abstract | A New Classification Plot for the C-Peptide Suppression Test

JOP. Journal of the Pancreas
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Context and objective To evaluate the Cpeptide suppression test as a screening test in patients with symptoms of hypoglycemia as compared to the standard fasting test. Design Retrospective discriminant analysis of data from C-peptide suppression tests. Setting :Clinical study. Patients Two different sets: patients with insulinomas and patients without insulinomas but having symptoms compatible with hypoglycemia. Interventions The results from C-peptide suppression tests of 26 patients with insulinomas and 100 patients without insulinomas were compared. Main outcome measures A classification plot which introduces two discriminant parameters for the C-peptide suppression test: the ratio of [blood glucose]/[C-peptide] at the lowest C-peptide concentration and mean glycemia during insulin infusion. Results In patients with insulinomas, minimal serum C-peptide levels were higher (1.81±0.87 ng/mL; median 1.83 ng/mL; maximal suppression 37±24% of basal Cpeptide levels) as ompared to patients without insulinoma (0.40±0.15 ng/mL; median 0.30 ng/mL; maximal suppression of75±9%; P0.001). ean glycemia during the test was lower in patients with insulinomas (30.8±3.3 vs. 47.5±8.3 mg/dL; P0.001) as was te [blood glucose]/[C-peptide] ratio(21.9±14.6 vs. 139.2±43.8; P0.001). Discrminant analysis revealed a specificity of 96% to rule out the diagnosis of ‘insulinoma’ at a 1% probability threshold with a sensitivity of 100%. Conclusions We developed a new classification plot for the C-peptide suppression test in order to accurately identify those patients whose symptoms of hypoglycemia are not due to ndogenoushyperinsulinemia/insulinomas. Thus, the need for fasting tests and hospitalization costs can be reduced.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Christiane Saddig Achim AR Starke Ralf Bender

Keywords

C-Peptide (diagnostic use, secretion), Hypoglycemia (diagnosis), Insulinoma (diagnosis, secretion), Laboratory Techniques and Procedures

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords