alexa Abstract | A new stability indicating HPLC method for related substances in zolmitriptan

Indian Journal of Pharmaceutical Sciences
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A sensitive, precise, specific, linear and stability indicating isocratic HPLC method was developed for the analysis of related substances in zolmitriptan. The potential known related substances are (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one (impurity I) and (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one (impurity II). The method can be used for the detection and quantification of known and unknown impurities and degradants in the drug substance zolmitriptan during routine analysis and also for stability studies in view of its capability to separate degradation products.

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Author(s): E K S Vijayakumar MA Samel SB Bhalekar SM Pakhale


Forced degradation, HPLC, method development, related substances, zolmitriptan

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