alexa Abstract | A one pot synthesis of 1,3-benzoxazines from schiff’s bases

Der Pharmacia Sinica
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Research Article Open Access

Abstract

New Schiff bases (1-6) were prepared and reduced by using NaBH4 to 2-(2-aminoaryl)-methyl phenol; which were refluxed without isolation of reduced product with formaldehyde to afford 1,3-benzoxazines in good yields (13-18). Same series of 1,3-benoxazines were prepared stepwise. Schiff bases were reduced to 2-(2-aminoaryl) methyl phenols (7-12), which were refluxed with formaldehyde in ethanol to give 1,3-benzoxazine.

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Author(s): Archana Y Vibhute Sainath B Zangade Shivaji B Chavan and Yeshwant B Vibhute

 
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