700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Research Paper Open Access
A quantitative structure activity relationship (QSAR) study was made on the antileishmanial activity of substituted pyrimidine, and pyrazolo [1,5-a] pyrimidine analogues using physicochemical and steric descriptors of the varying substituents. The study of pyrimidine analogues indicated the necessity of having unsubstitued pyramidine N(3) for Antileishmanial activity. Also, the C(2) substituent, which is adjacent to N(3), of pyrimidine imporsed steric restrictions for a compound to become leishmanicide. In case of pyrazolo [1,5-a] pyrimidine analogues, the study suggested the role of hydrophobicity and polarity of substituents on antileishmanial activity.
To read the full article Peer-reviewed Article PDF
Author(s): Y S Prabhakar V J Ram