alexa Abstract | A Quantitative Structure - Activity Relationship Analysis Of Some Nimesulide Analogues Using Computer - Aided Molecular Modeling

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


The structures of a series of anti-inflammatory 2'-(2, 4-difluorophenoxy)-4' substituted methanesulfonilides were submitted to a molecular modeling software and after energy minimization and conformational analysis of the structures, a number of electronic, spatial and thermodynamic descriptors were calculated. The result of the quantitative structure-activity relationship (QSAR) analysis showed that the oral anti-inflammatory activity, as determined in the rat adjuvant arthritis model, was highly correlated with the X-component of the principal moment of inertia. Dipole moment of the molecules and energy of the highest occupied molecular orbital were also important in determining the activity of the molecules.

To read the full article Peer-reviewed Article PDF image

Author(s): S K Chakravarti S Ajmani Meena Tiwari S C Chaturvedi

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version