alexa Abstract | A rational approach for synthesis, characterization and antihypertensive activity evaluation of 1-(4-{5-amino-6-fluoro-1-[2'-(2H-tetrazole-5-yl)- biphenyl-4-ylmethyl]-1H-benzoimidazol-2-yl}-phenyl)-3-chloro-4- (substituted -phenyl)-azetidin-2-ones

Der Pharmacia Sinica
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Research Article Open Access

Abstract

A new series of 1-(4-{5-Amino-6-fluoro-1-[2'-(2H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-1Hbenzoimidazol- 2-yl}-phenyl)-3-chloro-4-(Substituted -phenyl)-azetidin-2-one derivatives MCS 06[1-15] has been synthesized and subjected to evaluate their antihypertensive activity. All the synthesized compounds of the series elicit remarkable activity in comparison to standard drug (Losartan). Structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data.

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Author(s): M C Sharma D V Kohli Smita Sharma and A D Sharma

Keywords

azetidin-2-one, Angitotensin II, Losartan, antihypertensive agents

 
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