alexa Abstract | A Sample And Sensitive Reverse-Phase High Performance Liquid Chromatographic Method For The Determination Of Celecoxib In Rat Plasma

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


A simple reversed-phase liquid chromatography method was developed for the quantitative determination of cyclooxygenase-2 inhibitor celecoxib in small volume of rat plasma. The method is simple, sensitive, and highly selective and involves single step extraction of plasma with methanol, with as low as 0.1 ml of rat plasma. The retention time of celecoxib was 5.4 min. The method has been validated for linearity precision, accuracy and inter- intra day variation. Recoveries of celecoxib were around 78 % over the calibration curve range. The method was found to be suitable in studying the pharmacokinetic aspects of celecoxib during the preliminary studies in rats.

To read the full article Peer-reviewed Article PDF image

Author(s): MN Reddy P Sujatha AS Chauhan S Ramakrishna PV Diwan

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us