alexa Abstract | A Simple And Sensitive HPTLC For The Determination Of Content Uniformity Of Atorvastatin Calcium Tablets

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

A simple, sensitive HPTLC method was developed for the analysis of atorvastatin calcium in its commercial single component tablet formulations (10 mg/tablet). The stationary phase was precoated silica gel 60 F254. The mobile phase used was a mixture of benzene: methanol, (7:3 v/v). Combination of benzene: methanol offered optimum migration (RF=0.46±0.02). Detection of the spots was carried out at 281 nm. The method was validated in terms of linearity (200-600 ng/spots), precision (intra-day variation: 0.25 to 1.01%, inter-day variation: 0.21 to 0.88%), accuracy (99.2±0.48) and specificity. The limit of detection and limit of quantification for atorvastatin calcium were found to be 40 ng/spot and 200 ng/spot, respectively. The proposed method was successfully applied to determine atorvastatin calcium content of 10 individual tablet units o f two market formulations, after extracting atorvastatin calcium with methanol. Both the formulation complied with the USP specifications (RSD less than or equal to 6 %) of the content uniformity test. The proposed HPTLC method can analyse ten or formulation units simultaneously on a single plate and provides a faster and cost-effective quality control tool for routine analysis of atorvastatin calcium tablet formulation.

To read the full article Peer-reviewed Article PDF image

Author(s): Savita S Yadav Deepali V Mhaske A B Kakad B D Patil S S Kadam S R Dhaneshwar

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords