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Research Article Open Access
A validated reverse phase high performance liquid chromatography method has been developed for the simultaneous determination of Dexrabeprazole and Domperidone in combined dosage form. Chromatography was carried out on a C-18 column (4.6 mm × 250 mm, 5 μm) using Acetonitrile: 0.025 M potassium dihydrogen orthophosphate buffer (pH adjusted to 5.1 with triethylamine) in the ratio of 30:70 (v/v) as the mobile phase at a flow rate of 1.0 mL/min and eluents were monitored at 284 nm. The calibration curves were linear over the range of 10 - 50 μg/mL for Dexrabeprazole and 20 – 100 μg/mL for Domperidone. The average retention time of Dexrabeprazole and Domperidone was found to be 9.28 min and 6.66 min respectively. The results of the analysis have been validated statistically and by recovery studies.
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Author(s): Sohan S Chitlange Amir I Mulla Ganesh R Pawbake and Sagar B Wankhede
Dexrabeprazole sodium, Domperidone, RP-HPLC, Validation.