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Original Articles Open Access
During several years the usage of immediate releases formulations was a traditional mode of treatment for diseases. These formulations were supposed to release the drug without any delay after administration. But the problem with these formulations is they will not release the drug for prolonged periods of time and also the management of a chronic disease with conventional formulation are very difficult. To rectify this problem, modified release system had come into picture which will prolong the release of drug from the formulation for larger periods of time. They will also be helpful in maintaining the chronic disease very well with lesser no. of dose to be given per day which is fetched by the higher amount of drug loaded in the dosage form initially to prolong the release of drug. This high amount of drug in the dosage form lead to dose is dumping and misuse of drug especially in habit forming drugs. To keep a check on this misuse, abuse resistant dosage forms had come into the picture which gained good interest of researchers to develop various techniques. In this review article we had made an attempt to discuss some of the important issues of abuse resistant dosage forms.
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Author(s): P Tripura Sundari M Sumakanth and Soumya Reddy
Conventional dosage forms, Dose dumping, Drug abuse, Abuse resistance, dosage forms