alexa Abstract | Acute toxicity and phytochemical screening of stem bark extracts of Entandrophragma angolense (Welw.) C.DC. (Meliaceae)

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The plants are a rich source of drugs because they produce a variety of bioactive molecules, most of which probably act as chemical defence against predators or pathogens. The present study was conducted to determine the phytochemical constituents and the acute toxicity of aqueous extracts, ethanolic and methanolic of stem bark from Entandrophragma angolense in rats. The acute toxicity studies were carried out on the basis of the guidelines of the OECD 423. The aqueous extracts, ethanolic and methanolic were administered orally at a single dose of 300, 2000 and 5000 mg / kg body weight to the rats. The extracts showed lesser toxicity at dose of 2000 mg / kg body weight; however at 5000 mg/kg body weight dose the mortality rate was 2/3. Thus, the Lethal Dose 50(DL50) is in the range of 2000 to 5000 mg / kg body weight. These results suggest that the aqueous extracts, ethanolic and methanolic of stem bark of E. angolense could be used with some degree of safety by oral route. Phytochemical analysis of aqueous extracts, ethanolic and methanolic of stem bark of E. angolense revealed the presence of alkaloids, saponins, tannins, flavonoids, terpenoids, quinones, cardiac glycosides, leucoanthocyanins, phenols and steroids. These extracts contain important bioactive compounds, which justifies the use of this plant in traditional medicine for the treatment of various diseases.

To read the full article Peer-reviewed Article PDF image

Author(s): Yenon A Houphouet YF AybEdwige K YapoAdou F Nguessan Jean D DjamanAllico J

Keywords

Entandrophragma angolense, Phytochemical analysis, Acute toxicity

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords